27th Annual Matthew & Marcia Simons Research Symposium on Alzheimer's Disease

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Moving Towards Precision Medicine in Alzheimer’s Disease


Research over the last decade have supported the notion that Alzheimer’s disease is a relatively heterogeneous condition in which individuals vary in the nature of what aspects of thinking are most affected (for example, memory or language) and the speed in which the disease progresses. Moreover, much recent work has shown that often Alzheimer’s disease is associated not only with the amyloid “plaques” and tau “tangles” that are a hallmark of the disease, but additional brain pathologies, such as cerebrovascular disease and pathologies more commonly associated with other “neurodegenerative” conditions. Making sense of this heterogeneity is of critical importance to not only diagnosis, but to how we effectively treat the disease. Precision medicine involves the targeting of interventions based on the specific characteristics of the individual patient and has been increasingly successful in other areas of medicine, such as cancer. Dr. Wolk will discuss a path towards bringing precision medicine into Alzheimer’s disease research and clinical care.


About the Speaker

Dr. David Wolk is an Associate Professor of Neurology in the Cognitive Neurology Division of the University of Pennsylvania Perelman School of Medicine. He is also Co- Director of the Penn Memory Center and Associate Director of Penn’s Alzheimer’s Disease Core Center (Leader of the Clinical Core). His primary clinical interest has been in the diagnosis and care of individuals with a variety of neurodegenerative conditions. Dr. Wolk’s research has focused on the cognitive neurosience of memory decline associated with aging and Mild Cognitive Impairment/Alzheimer’s Disease. A highly related additional line of his work has been the development and examination of biomarkers for detection of early disease changes that differentiate normal aging from evidence of neurodegenerative pathophysiology.

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David Wolk, MD

David Wolk, MD

Associate Professor of Neurology,
University of Pennsylvania;
Co-Director, Penn Memory Center;
Associate Director, Alzheimer’s Disease Core Center

Wednesday November 29th, 2017
6:30pm Reception – Light Refreshments will be served
7:00pm Program

Boston Marriott Newton Hotel
2345 Commonwealth Avenue
Newton, MA 02466 USA 

Parking on site.

Free and Open to the Public! 

Since 1991, the annual Matthew & Marcia Simons Research Symposium on Alzheimer’s disease has been the centerpiece of the Alzheimer’s Association, MA/NH Chapter’s yearly scientific presentations, highlighting the work of scientists making major contributions to the search for causes, treatments and ultimate cure for Alzheimer’s disease.

The Alzheimer’s Association honors the spirit and dedication of longtime Board of Directors member Marcia Simons, whose commitment to support and education for those coping with Alzheimer’s disease led her in 1991 to endow The Matthew & Marcia Simons Research Symposium on Alzheimer’s Disease. Twenty-seven years later, the Alzheimer’s Association continues to honor Marcia Simons and her family by highlighting the work of scientists making major contributions to the search for causes, treatments and ultimate cure for Alzheimer’s disease.